Testosterone enanthate, also known as testosterone heptanoate, is an anabolic and androgenic steroid (AAS) drug used to treat low testosterone levels. Anabolic drugs work by building muscles, while androgenic refers to the enhancement of male sex characteristics.
Used in medical procedures since the 1950s, testosterone enanthate is marketed under numerous brand names, including Androfil, Andropository, Cernos, Delatestryl, Depandro, Durathate, Everone, Sustrone, Testanon, Testanova, Testrin, Testostroval, Testoviron, and Testro
As a schedule III drug, testosterone enanthate is available by prescription only and is classified as a prohibited substance by the World Anti-Doping Agency.
Testosterone enanthate is classified as an AAS because it is both a synthetic derivative of testosterone and a testosterone pro-drug, meaning that it stimulates the body to produce testosterone on its own. With that being said, it has stronger androgenic effects and only moderate anabolic effects.
The drug is suitable for testosterone replacement therapy (TRT) in men with hypogonadism (the diminished production of testosterone in the testes). Causes of hypogonadism include testicular injury, infection, and cancer. Radiation and chemotherapy can also cause hypogonadism, as can congenital disorders such as Klinefelter syndrome and diseases of the hypothalamus and pituitary gland (both of which stimulate testosterone production).
Testosterone levels in men can often decline steeply after the age of 50, leading to a condition known as andropause in which vigor and sexual desire are affected. Older men with symptoms of andropause (including fatigue and low libido) will often benefit from TRT.
Testosterone enanthate can also be used for hormone therapy in transgender men, to treat delayed puberty in boys, to ease menopause symptoms, and to manage inoperable metastatic breast cancer (breast cancer that has spread) in postmenopausal women.
The drug is also sometimes used, controversially, as an anti-aging therapy in older men.