Steroid Recipe Homebrew

Drostanolone propionate (Masteron propionate ) recipe

Drostanolone propionate (Masteron propionate )

IDENTIFICATION

Name : Drostanolone propionate
Accession Number : DB14655  (DBSALT001342)
Type : Small Molecule
Groups :  Approved, Illicit
Description : Not Available
Structure
Thumb
Synonyms
  • 17β-Hydroxy-2α-methyl-5α-androstan-3-one propionate
  • 2M-DHTP
  • 2MDTP
  • 2α-Methyl-4,5-dihydrotestosterone propionate
  • Blackburn Compound
  • Dromostanolone propionate
  • Emdisterone
  • Testosterone, 4,5α-dihydro-2α-methyl-, propionate
External IDs
Re 346 / RS 1567
International/Other Brands
Drolban (Lilly) / Masteril (Syntex) / Masteron (Recordati)
Categories
UNII : X20UZ57G4O
CAS number : 521-12-0
Weight : Average: 360.538
Monoisotopic: 360.266445019
Chemical Formula : C23H36O3
InChI Key : NOTIQUSPUUHHEH-UXOVVSIBSA-N
InChI  :  InChI=1S/C23H36O3/c1-5-21(25)26-20-9-8-17-16-7-6-15-12-19(24)14(2)13-23(15,4)18(16)10-11-22(17,20)3/h14-18,20H,5-13H2,1-4H3/t14-,15+,16+,17+,18+,20+,22+,23+/m1/s1
IUPAC Name  : (1S,3aS,3bR,5aS,8R,9aS,9bS,11aS)-8,9a,11a-trimethyl-7-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl propanoate
SMILES :  [H][C@@]12CC[C@H](OC(=O)CC)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)[C@H](C)C[C@]12C

PHARMACOLOGY

Indication
For use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
Pharmacodynamics
Dromostanolone is a synthetic androgen, or male hormone, similar to testosterone. Dromostanolone works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.
Mechanism of action
Dromostanolone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Absorption  :  Well absorbed following parenteral administration.
Volume of distribution  : Not Available
Protein binding : Not Available
Metabolism  : Not Available
Route of elimination :  Not Available
Half life  :  Not Available
Clearance  :  Not Available
Toxicity  :  Side effects include virilization (masculine traits in women), acne, fluid retention, and hypercalcemia.
Affected organisms  :  Not Available
Pathways  :  Not Available
Pharmacogenomic Effects/ADRs  :  Not Available

INTERACTIONS

Drug Interactions

ADDITIONAL DATA AVAILABLE

EXTENDED DESCRIPTION
Extended Description

Extended description of the mechanism of action and particular properties of each drug interaction.

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  • SEVERITY

    Severity

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  • EVIDENCE LEVEL

    Evidence Level

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  • ACTION

    Action

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Food Interactions
Not Available

REFERENCES

General References  : Not Available
External Links
KEGG Drug  : D01534
ChemSpider   :  194604
ChEBI   :  31523
ChEMBL  :  CHEMBL1201048
PharmGKB   :  PA164760855
Wikipedia  :  Drostanolone_propionate

CLINICAL TRIALS

Clinical Trials  : Not Available

PHARMACOECONOMICS

Manufacturers : Not Available
Packagers : Not Available
Dosage forms  :  Not Available
Prices  :  Not Available
Patents  :  Not Available

PROPERTIES

State  :  Not Available
Experimental Properties  : Not Available
Predicted Properties
PROPERTY VALUE SOURCE
Water Solubility 0.000631 mg/mL ALOGPS
logP 4.76 ALOGPS
logP 5.1 ChemAxon
logS -5.8 ALOGPS
pKa (Strongest Basic) -6.9 ChemAxon
Physiological Charge 0 ChemAxon
Hydrogen Acceptor Count 2 ChemAxon
Hydrogen Donor Count 0 ChemAxon
Polar Surface Area 43.37 Å2 ChemAxon
Rotatable Bond Count 3 ChemAxon
Refractivity 101.96 m3·mol-1 ChemAxon
Polarizability 43.19 Å3 ChemAxon
Number of Rings 4 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five No ChemAxon
Ghose Filter Yes ChemAxon
Veber’s Rule No ChemAxon
MDDR-like Rule No ChemAxon
Predicted ADMET features  : Not Available

SPECTRA

Mass Spec (NIST)  : Not Available
Spectra  ;  Not Available

TAXONOMY

Description
This compound belongs to the class of organic compounds known as steroid esters. These are compounds containing a steroid moiety which bears a carboxylic acid ester group.
Kingdom  : Organic compounds
Super Class  :  Lipids and lipid-like molecules
Class  :   Steroids and steroid derivatives
Sub Class  :  Steroid esters
Direct Parent  :  Steroid esters
Alternative Parents   :  Androgens and derivatives / 3-oxo-5-alpha-steroids / Cyclic ketones / Carboxylic acid esters / Monocarboxylic acids and derivatives / Organic oxides / Hydrocarbon derivatives
Substituents  :   Steroid ester / Androgen-skeleton / Androstane-skeleton / 3-oxosteroid / 3-oxo-5-alpha-steroid / Oxosteroid / Cyclic ketone / Carboxylic acid ester / Ketone / Carboxylic acid derivative
Molecular Framework   :  Aliphatic homopolycyclic compounds
External Descriptors   :  steroid ester (CHEBI:31523)

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